Muscarinic M1 receptor sequence: Preliminary studies on its effects on cognition and expression

E Scarr; S Sundram; A Deljo; TF Cowie; AS Gibbons; S Juzva; A Mackinnon; SJ Wood; R Testa; C Pantelis; B Dean

Journal article

Muscarinic M1 receptor sequence: Preliminary studies on its effects on cognition and expression

E Scarr, S Sundram, A Deljo, TF Cowie, AS Gibbons, S Juzva, A Mackinnon, SJ Wood, R Testa, C Pantelis, B Dean

Schizophrenia Research | Published : 2012

DOI: 10.1016/j.schres.2012.02.011

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Abstract

It has been reported that people with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism of the cholinergic muscarinic M1 receptor (CHRM1) perform less well on the Wisconsin Card Sorting Test than those who are heterozygous. We investigated whether CHRM1 sequence is associated with impaired executive function, a common problem in schizophrenia. We sequenced the CHRM1 using peripheral DNA from 97 people with schizophrenia who completed the Wisconsin Card Sorting Test, a verbal fluency test and the National Adult Reading Test. Clinical severity was assessed using the Positive and Negative Syndrome Scale. To determine whether CHRM1 sequence affected receptor express..

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University of Melbourne Researchers

Andrew MacKinnon Author

Stephen Wood Author

Christos Pantelis Author

Brian Dean Author Florey Department of Neuroscience and Mental Health

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Awarded by MedStar Health Research Institute

Funding Acknowledgements

[ "Funding for this study was provided by Australian Rotary Health (ES was the ARH Royce Abbey Post-doctoral Fellow) and the NHMRC; CP is an NM&HRC Senior Principal Research Fellow (#628386), BD is an NH&MRC Senior Research Fellow (#APP1002240). This work was supported, in part, by NM&HRC project grants 509333, 628669 and 566967 as well as Operational Infrastructure Support (OIS) from the Victorian State Government. None of the Funding Sources played any role in the study design; collection, analysis or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.", "ASG, TFC, SJ, AM, SJW and RT report no competing interests. The following authors have received remuneration in the past: ES received honorarium from AstraZeneca and travel support from GSK. SS has received speakers bureau honoraria, travel funds, advisory panel payments or research grants from AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen-Cilag, Lundbeck, Organon, Pfizer and Sanofi. AK received travel funds. CP has received grant support, travel or consultancy fees from Janssen-Cilag, Eli Lilly, Hospira (Mayne), AstraZeneca, Pfizer and Schering Plough. BD received travel support from GSK, honorarium from Pfizer, Eli Lilly and MSD.", "Tissues were received from the Victorian Brain Bank Network, which is supported by the Mental Health Research Institute, The Alfred, Victorian Forensic Institute of Medicine, The University of Melbourne and funded by Australia's National Health & Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services." ]